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Department of Surgery » Anatomy » Faculty » C. Morshead

Professor Cindi Morshead

Ph.D.

Dr. Morshead received her PhD at the University of Toronto in the Department of Anatomy and Cell Biology. She teaches Neuroanatomy in the MScPT Program in Rehabilitation Sciences, as well as contributes to the Neuroanatomy course of the Brain and Behaviour block of first year medicine.

Dr. Morshead’s academic interests include the study of neural stem cells in the adult mammalian central nervous system. She is a member of the Stem Cell Network and Toronto Stem Cell Group. Her research is focused on the fundamental characterization of neural stem cells and their potential role in neural regeneration in the adult brain. She is currently using in vivo transplantation and injury models in addition to in vitro models to manipulate neural stem cells and examine their lineage commitment. Some of the in vitro models involves live cell imaging techniques to visualize and follow individual stem cells and their progeny in controlled microenvironments. In addition, the lab is interested in the use of biomaterials in combination with neural stem cells towards the ultimate goal of enhancing the regenerative capacity of the nervous system.

Select Publications:
Morshead CM
, Reynolds BA, Craig CG, McBurney MW, Staines WA, Morassutti D, Weiss S, and van der Kooy D (1994) Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells. Neuron 13:1071-1082.

Morshead CM, Craig CG and van der Kooy D (1998) In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain. Development 125:2251-2261.

Morshead CM, Benveniste P, van der Kooy, D and Iscove, N.N. (2002) Hematopoietic competence is a rare property of neural stem cells and may depend on cell transformation and genetic mutation. Nature Medicine, 8(2): 268-273

Morshead CM, Garcia AD, Sofroniew MV and van der Kooy D. The ablation of GFAP positive cells from the adult CNS results in the loss of forebrain neural stem cells but not retinal stem cells. Eur J Neurosci, 18:76-84.

Kim M, and Morshead CM (2003) Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis. J. Neurosci, in press

Publications:
www.ncbi.nlm.nih.gov/PubMed/

The Morshead Lab


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