The Hospital for Sick Children

Division of Urology

Dr. D.J. Bagli - Associate Professor
Dr. L.L. Burrows - Assistant Professor
Dr. W. Farhat - Assistant Professor
Dr. A.E. Khoury - Professor (Division Head)

Publications

Aboutaleb H, Bolduc S, Upadhyay J, Farhat W, Bagli DJ, Khoury AE: Subureteral Polydimethylsiloxane Injection Versus Extravesical Reimplantation for Primary Low Grade Vesicoureteral Reflux in children: A Comparative Study. Journal of Urology: January 2003: 163: pp 313-316.

Aboutaleb H, Bolduc S, Upadhyay S, Farhat W, Bagli DJ, Khoury AE: Subureteral Polydimethylsiloxane Injection Versus Extravesical Reimplantation for Primary Low Grade Vesicoureteral Reflux in Children: A Comparative Study. Journal of Urology: January 2003: 169: pp 313-316.

Bagli DJ: On the Cell & Molecular Biology of the Posterior Urethral Valve Bladder. In: Progress in Paediatric Urology Volume 4 (Bajpai M, Gearhart JP, Hjalmas K, Mitra DK, Radhakrishnan J, Etker S, eds). Penwl Publishers PLC, New Delhi, India: 2002: pp 1-10.

Bagli DJ: Tribute for Michael E. Mitchell. In: Progress In Paediatric Urology Volume 4 (Bajpai M, Gearhart JP, Hjalmas K, Mitra DK, Radhakrishnan J, Etker S, eds). Penwel Publishers PLC, New Delhi, India: 2002: pp VII.

Bolduc S, Capolicchio GP, Upadhyay J, Bagli D, Khoury AE, McLorie GA: The fate of the upper tract in exstrophy. Journal of Urology: December 2002: 168: pp 2579-2582.

Bolduc S, Capolicchio GP, Upadhyay J, Bagli D, Khoury AE, McLorie GA: The fate of the upper urinary tract in exstrophy. Journal of Urology: December 2002: 168: pp 2579-2582.

Bolduc S, Upadhyay J, Farhat W, Sherman C, Bagli DJ, Mclorie GA, Khoury AE, EL Ghoneimi: Histology of upper pole is unaffected by antenatal diagnosis in duplex system. The Journal of Urology: September 2002: 168(3): pp 1123-1126.

Bolduc S, Upadhyay J, Farhat W, Sherman C, Bagli DJ, Mclorie GA, Khoury AE, El Ghoneimi A: Histology of upper pole is unaffected by antenatal diagnosis in duplex system ureteroceles. The Journal of Urology: September 2002: 168(3): pp 1123-1126.

Bolduc S, Upadhyay J, Payton J, Aboutaleb H, Bagli DJ, McLorie GA, Khoury AE, Farhat W: The Use of tolterodine in children after oxybutinin failure. British Journal of Urology: March 2003: 91(4): pp 398-401.

Bolduc S, Upadhyay J, Restrepo R, Sherman C, Farhat W, Bagli D, McLorie GA, Khoury AE, EL Ghoneimi A: The predictive value of diagnositc imaging ureteroceles. British Journal of Urology: May 2003: 91(7): pp 678-682.

Bolduc S, Upadhyay J, Restrepo R, Sherman C, Farhat W, Bagli DJ, McLorie GA, Khoury AE, EL Ghoneimi A: The predictive value of diagnostic imaging for histologic lesions of upper poles in duplex systems with ureteroceles. British Journal of Urology: June 2003: 3(&): pp 678-682.

Bolduc S, Upadhyay J, Sherman C, Farhat W, Bagli D, McLorie G, Khoury AE, El Ghoneimi A: Histology of upper pole is unaffected by prenatal diagnosis in duplex system ureteroceles. Journal of Urology: September 2002: 168: pp 1123-1126.

Burrows LL: Invited commentary on: “Device Removal”. In: Source Control (Schein M, Marshall JC, eds). Springer-Verlag,: 2003: pp 51-53.

El-Ghoneimi A, Farhat W, Bolduc S, Bagli D, McLorie G, Khoury AE: Retroperitoneal Laparoscopic vs. Open Partial Nephroureterectomy in Children. British Journal of Urology: April 2003: 91(6): pp 532-535.

Farhat W, McLorie GA: Posterior Urethral Valves. In: Progress in Paediatric Urology Volume 4 (Bajpai M, Gearhart JP, Hjalmas K, Mitra DK, Radhakrishnan J, Etker S, eds). Penwell Publishers PLC, New Delhi, India: 2002: pp 128-137.

Farhat W, Mclorie GA: Posterior Urethral Valves. In: Progress In Paediatric Urology Volume 4 (Bajpai, M, Gearhart JP, Hjalmas K, Mitra DK, Radhakrishnan J, Etker S, eds). Penwel Publishers PLC, New Delhi, India: 2002: pp 128-137.

Farhat W, Traubicci J, Sherman C, Williams T, Babyn P, McLorie G: Reliability of contrast-enhanced sonography with harmonic imaging in detecting early renal scarring in experimental pyelonephritis in porcine model: Preliminary results. The Journal of Urology: September 2002: 168(3): pp 1114-1117.

Finelli A, Gallant CV, Jarvi K, Burrows LL: In-Biofilm Expression Technology (IBET) approach to identification of genes involved in Pseudomonas aeruginosa biofilm development. Journal of Bacteriology: May 2003: 185: pp 2700-2710.

Gardam MA, Burrows LL, Kus JV, Brunton J, Low D, Conly JM, Humar A: Is surveillance for multidrug-resistant Enterobacteriaceae an effective infection control strategy in the absence of an outbreak? Journal of Infectious Diseases: December 2002: 186: pp 1754-1760.

Hafez A, Bagli DJ, Bahoric A, Aitken K, Smith C, Herz D, Khoury AE: Aerosol Transfer of Bladder Urothelial and Smooth Muscle Cells (SMCs) Onto-De-Mucosalized Colonic Segments. Journal of Urology: June 2003: 169: pp 2316-2320.

Hafez A, Herz D, Bagli DJ, Smith C, McLorie GA, Khoury AE: Healing of non-stented tubularized incised plate urethroplasty: Experimental study in a rabbit model. British Journal of Urology: January 2003: 91(1): pp 84-88.

Hafez A, McLorie GA, Bagli DJ, Khoury AE: Trend analysis with serial ultrasound for high-grade neonatal hydronephrosis. The Journal of Urology: October 2002: 168: pp 1518-1521.

Hafez AT, Bagli DJ, Herz DB, Smith CR, McLorie GA, El-Ghoneimi A, Khoury AE: Healing of Unstented Tubularized Incised Plate Urethroplasty: An Experimental Study in a Rabbit Model. British Journal of Urology: January 2003: 91(1): pp 84-88.

Hafez At, McLorie GA, Bagli DJ, Khoury AE: Trend analysis with serial ultrasound for high grade neonatal hydronephrosis. The Journal of Urology: October 2002: 168: pp 1518-1521.

Halachmi S, Chait P, Hodapp J, Bagli DJ, McLorie GA, Khoury AE, Farhat W: Renal pseudoaneurysm following blunt renal trauma in a pediatric patient; management by angiographic embolization. Urology: January 2003: 61: pp 224-226.

Halachmi S, El-Ghoneimi A, Farhat W: Successful subcapsular laparoscopic nephrectomy in a child with xanthogranulomatous pyelonephritis. The Journal of Pediatric Endosurgery & Innovative Techniques/Winter 20026(4)269-27211NO: February 2003: 6(4): pp 269-272.

Hammouda H, EL-Ghoneimi A, Bagli DJ, McLorie GA, Khoury AE: Tubularized Incised Plate Repair: Functional Outcome After Intermediate Followup. Journal of Urology: January 2003: 169: pp 331-333.

Hirji Z, Saragosa R, Dedier H, Crump M, Franke N, Burrows LL, Jamieson F, Brown S, Gardam MA: Contamination of bone marrow products with an actinomycete resembling Microbacterium spp. and reimfusion into autologous stem cell and bone marrow transplant recipients. Clinical Infectious Disease: May 2003: 36: pp e115-e121.

McLorie GA: Editorial-Posterior Urethral Valves. In: Progress in Paediatric Urology (Bajpai M, Gearhart JP, Hjalmas K, Mitra DK, Radhakrishnan J, Etker S, eds). Penwel Publishers PLC, New Delhi, India: 2002: pp XIX-XX.

Pepperell C, Kus JV, Gardam MA, Humar A, Burrows LL: Low-virulence Citrobacter spp. encode resistance to multiple antimicrobial classes. Antimicrobial Agents and Chemotherapy: November 2002: 46: pp 3555-3560.

Richardson DC, Burrows LL, Korithoski B, Salit IE, Butany J, David TE, Conly JM: Tropheryma whippelii as a cause of afebrile culture-negative endocarditis: the evolving spectrum of whipple’s disease. Journal of Infectious Diseases: May 2003: 47.

S. Halachmi, P. Chait, J. Hodapp, D. Bagli, GA. McLorie, AE Khoury, W Farhat: Renal pseudoaneurysm following blunt renal trauma in a pediatric patient; management by angiograhic embolization. Urology: January 2003: 61: pp 224-226.

Upadhyay J, Aitken K, Gu J, Damdar C, Bolduc S, Bagli DJ: Integrins are coordinately expressed with bladder extracellular matrix following stretch injury in VIVO and mediate bladder smooth muscle cell growth in VITRO. Journal of Urology: February 2003: 169: pp 750-755.

Upadhyay J, Bolduc S, Bagli D, McLorie GA, Khoury AE, Farhat W: Natural history of neonatal reflux asociated with antenatal hydronephrosis long-term results of a prospective study. Journal of Urology: May 2003: 169(5): pp 1837-1841.

Upadhyay J, Bolduc S, Bagli DJ, McLorie GA, Khoury AE, Farhat W: Use of the Dysfuncitonal Voiding Symptom Score to Predict Resolution of Vesicoureteral Reflux in children with Voiding Dysfunction. Journal of Urology: May 2003: 169(5): pp 1842-1846.

Upadhyay J, Restrepo R, Hebert D, Chait P, McLorie GA: Long term outcome of bilateral autotransplantation in a child with Tekayasu’s disease. The Journal of Urology: December 2002: 168: pp 2566-2567.

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Invited Visits to other Hospitals/Universities

Bagli, DJ: International Bladder Research Symposium NIDDK (NIH) and National Bladder Foundation (US), Washington, District of Columbia, March 2003. Mechanical and Matrix Signaling Induction in Bladder Smooth Muscle.

Burrows LL: Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, November 2002. Genes involved in development Pseudomonas aeruginosa biofilms.

Burrows LL: Materials and Manufacturing Ontario- Project Group Meeting University of Guelph, Guelph, Ontario, November 2002. Polymer and Biofilm Modification of Surfaces: Emerging Materials Knowledge Title: Formation of Pseudomonas biofilms and antibiofilm strategies.

Khoury AE: North shore-Long Island Jewish Medical Center, New York, New York, May 2003. Contemporary studies in bladder reconstruction: New directions from Toronto.

Khoury AE: Pediatric Surgery at the Universidade Catolica de Curitiba, Curitiba, Brazil, July 2002. Correction of a female Pseudohemafroditism.

Khoury AE: 2nd International Symposium on Exstrophy & Epispadias, Baltimore, Maryland, October 2002. Is there a need for bladder neck reconstruction in exstrophy.

Khoury AE: 2nd International Symposium on Exstrophy & Epispadias, Baltimore, Maryland, October 2002. Moderator/Cloacal Exstrophy.

Khoury AE: North Shore-Long Island Jewish Health System, New York, New York, May 2003. Principles and applications of reconstructive techniques in hypospadias surgery.

Khoury AE: Mansoura University/Urology & Nephrology Center, Mansoura, Egypt, February 2003. Recent trends in pediatric urology.

Khoury AE: Mansoura University/Urology & Nephrology Center, Mansoura, Egypt, February 2003. Renal transplantation in children.

Khoury AE: Société Internationale D’Urologie, Stockholm, Sweden, September 2002. SIU International Course on The Management of Hypospadias.

Khoury AE: Pediatric Surgery at the Universidade Catolica de Curitiba, Curitiba, Brazil, July 2002. Surgical Treatment of Intersex (Ambiguous Genitalia).

Khoury AE: Pediatric Surgery at the Universidade Catolica de Curitiba, Curitiba, Brazil, July 2002. Surgical treatment of the bladder exstrophy today.

Khoury AE: Pediatric Surgery at the Universidade Catolica de Curitiba, Curitiba, Brazil, July 2002. Surgical Treatment of the Epispadias.

Khoury AE: Pediatric Surgery at the Universidade Catolica de Curitiba, Curitiba, Brazil, July 2002. Surgical treatment of urinary incontinence.

McLorie GA: 2nd International Symposium on Exstrophy & Epispadias, Baltimore, Maryland, October 2002. Determinants of success in bladder exstrophy repair.

McLorie GA: 2nd Internation Symposium on Exstrophy & Epispadias, Baltimore, Maryland, October 2002. Moderator/Bladder Exstrophy-Surgical Management.

McLorie GA: Children’s Hospital of Michigan, Detroit, Michigan, November 2002. The Complexity of Neurogenic Bladder.

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Research and Investigations

Senior Investigator’s Name Appears in Italics

A prospective randomized open label study to compare ciprofloxacin (intravenous sequential IV-Oral versus IV cefotaxime with or without IV gentamicin or oral TMP/SMX in the therapy of older infants, children and adolescents with complicated urinary tract infections or pyelonephritis. Khoury AE, Herz D: Bayer Inc. ($80,000 2000 - 2002).

Acellular Matrix Scaffolds with Bioactive Peptides for Bladder Augmentation. Woodhouse K, Bagli D, Ringutte M: CIHR ($87,000 2003 - 2005).

Antimicrobial activity of novel membrane-active peptides and synergy with conventional antibiotics. Burrows LL, Deber CM: Canadian Infectious Diseases Society (CIDS/Janssen-Ortho Antimicrobial Resistance Research Grant) ($45,000 2002 - 2003).

Development of antimicrobial coatings for peritoneal catheters suitable for simultaneous exchange. Antoine Khoury, Burrows LL, DiCosmo F: The Kidney Foundation of Canada ($96,088 2002 - 2004).

Development of antimicrobial liposomal silver formulations for medical devices. Burrows LL: UroTeq Inc. ($30,000 2002 - 2003).

Feasibility Of Contrast-Enhanced Sonography to Detect Pyelonephritis In a Pig Model. McLorie G, Farhat W: Hospital For Sick Children Research Institute- Seed Grant ($30,000 2002 - 2004).

Feasibility of contrast-enhanced sonography to detect pyelonephritis in a pig model. McLorie G, Farhat W: Research Institute- Seed Grant ($15,000 2002 - 2004).

Influence of cell surface mutations on Pseudomonas aeruginosa biofilm formation. Burrows LL: Canadian Institutes of Health Research ($78,767 2001 - 2003).

Novel adhesion-reducing biomaterials. Khoury AE, Burrows LL: Interface Biologics Inc. (sponsored research agreement) ($20,000 2002 - 2003).

Novel peptide antibiotics against pseudomonas aeruginosa. Burrows LL, Deber CM: NIH SCOR Pilot Project Program ($97,600 2002).

Pseudomonas aeruginosa biofilm gene expression. . Burrows LL: Natural Sciences and Engineering Research Council of Canada ($35,000 2001 - 2004).

The role of Erk MAP kinase in bladder smooth muscle cell response to injury. Bagli DJ: CIHR ($250,000 2002 - 2005).

Type IV pilus biogenesis in Pseudomonas aeruginosa. Howell PL, Burrows LL: PENCE (Protein Engineering Centre of Excellence), New Ideas Program ($40,000 2003 - 2004).

Use of tolterodine in treatment of neuropathic overactive bladders in children. Khoury AE, Farhat W: Pharmacia-Upjohn Canada ($63,700 2000 - 2003).

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Honours Received

Bagli, DJ: 1st prize Basic Science-Robson Research Day for Stat 3 Kinase in Bladder Stretch Injury (Sarel Halachmi presented), March 2003.

Bagli, DJ: 2nd Prize Basic Science-Robson Research Day for Dissociated autologous urolthelial grafting for bladder augmentation in a porcine model (John Hodapp presented), March 2003.

Bagli, DJ: 2nd Prize Clinical Research-Robson Research Day for The role of bacterial infection in pediatric acute epidydimo-orchitis (Sarel Halachmi presented), March 2003.

Burrows LL: Claude Gallant- won 3rd place (Basic Research) in the HSC Josie Walther Memorial Surgical Services competition “Using the IBET approach to monitor gene expression in Pseudomonas aeruginosa biofilms” (Dr. Lori Burrows-surpervisor), May 2003.

Khoury AE: 2nd Prize Basic Science-Robson Research Day for Dissociated autologous urolthelial grafting for bladder augmentation in a porcine model (John Hodapp presented), March 2003.

Khoury AE: 2nd Prize Clinical Research-Robson Research Day for The role of bacterial infection in pediatric acute epidydimo-orchitis (Sarel Halachmi presented), March 2003.

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